INNotope offers various 13C, 15N and 2H labeled RNA/DNA phosphoramidites for chemical RNA and DNA production using standard DNA/RNA synthesizers. The nucleic acids produced via this methods can be used for academic research in NMR or MS applications.
INNotope also offers 13C, 15N and 2H labeled RNA triphosphates, which can be directly used in RNA in vitro transcription.
RNA phosphoramidites
2′-O-TBS 5′-O-DMT 3′-CE phosphoramidite
RNA amidites with 13C label in nucleobase
[5-D, 6-13C]-uridine
pack size list price
50 mg 850 EUR
100 mg 1440 EUR
250 mg 3400 EUR
[5-D, 6-13C]-N4-Ac-cytidine
pack size list price
50 mg 850 EUR
100 mg 1440 EUR
250 mg 3400 EUR
[8-13C]-N6-Ac-adenosine
pack size list price
50 mg 850 EUR
100 mg 1440 EUR
250 mg 3400 EUR
[8-13C]-N2-Ac-guanosine
pack size list price
50 mg 850 EUR
100 mg 1440 EUR
250 mg 3400 EUR
RNA amidites with 15N label in nucleobase
[1,3-15N2]-uridine
pack size list price
50 mg 800 EUR
100 mg 1360 EUR
250 mg 3200 EUR
[1,3,4-15N3]-N4-Ac-cytidine
pack size list price
50 mg 800 EUR
100 mg 1360 EUR
250 mg 3200 EUR
[1-15N]-N6-Ac-adenosine
pack size list price
50 mg 800 EUR
100 mg 1360 EUR
250 mg 3200 EUR
[1-15N]-N2-Ac-guanosine
pack size list price
50 mg 900 EUR
100 mg 1530 EUR
250 mg 3600 EUR
modified DNA/RNA phosphoramidites
5′-O-DMT (2′-TBS) 3′-CE phosphoramidite
methylated RNA amidites with 13C labels
m6A-13CH3
[N6-13CH3]-adenosine
pack size list price
50 mg 1100 EUR
m6A-13C2,8
[N6-CH3]-13C2,8-adenosine
pack size list price
50 mg 1100 EUR
m1A-13CH3
[N1-13CH3]-adenosine N6-2-chloroacetyl
pack size list price
50 mg 1100 EUR
m3C-13CH3
[N3-13CH3]-cytidine N4-acetyl
pack size list price
50 mg 1100 EUR
methylated DNA amidites with 13C labels
m5dC-13CH3
[5-13CH3]-2′-deoxycytidine N4-acetyl
pack size list price
50 mg 1100 EUR
m6dA-13C2,8
[N6-CH3]-13C2,8-2′-deoxyadenosine
pack size list price
50 mg 1100 EUR
DNA phosphoramidites
5′-O-DMT 3′-CE phosphoramidite
DNA amidites with 13C label in nucleobase
[6-13C]-thymidine
pack size list price
50 mg 800 EUR
100 mg 1360 EUR
250 mg 3200 EUR
[5-D, 6-13C]-N4-Ac-2′-deoxycytidine
pack size list price
50 mg 800 EUR
100 mg 1360 EUR
250 mg 3200 EUR
[8-13C]-N6-Ac-2′-deoxyadenosine
pack size list price
50 mg 900 EUR
100 mg 1530 EUR
250 mg 3600 EUR
[8-13C]-N2-Ac-2′-deoxyguanosine
pack size list price
50 mg 900 EUR
100 mg 1530 EUR
250 mg 3600 EUR
DNA amidites with 15N label in nucleobase
[1,3-15N2]-thymidine
coming soon!
[1,3,4-15N3]-N4-Ac-2′-deoxycytidine
coming soon!
RNA triphosphates
RNA triphosphates are produced as triethylammonium salt form.
[5-D, 6-13C]-Uridine
coming soon!
[5-D, 6-13C]-Cytidine
coming soon!
[8-13C]-Adenosine
coming soon!
[8-13C]-Guanosine
coming soon!
Relevant References
- Excited states of nucleic acids probed by proton relaxation dispersion NMR spectroscopy. Juen MA, Wunderlich CH, Nußbaumer F, Tollinger M, Kontaxis G, Konrat R, Hansen DF*, Kreutz C.* Angew. Chem. Int. Ed. Engl. (2016);55(39):12008-12012. link
- A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer. Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J.* Angew. Chem. Int. Ed. Engl. (2017);56(1):401-404. link
- Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing. Plangger R, Juen M, Hoernes T, Nußbaumer F, Kremser J, Strebitzer E, Klingler D, Erharter K, Tollinger M, Erlacher M, Kreutz C.* Nucleic Acids Res. (2019); 47(21): 11430-11440. link
- NMR chemical exchange measurements reveal that N6-methyladenosine slows RNA annealing.
Shi H, Liu B, Nussbaumer F, Rangadurai A, Kreutz C*, Al-Hashimi HM.* J. Am. Chem. Soc. (2019); 141(51): 19988-19993. link